Nausea, Hunger Suppression, and the Weakness from the Past Week Continues
REMINDER: Retatrutide is not FDA-approved and is not commercially available. This is a personally supervised journey — my wife is a doctor. Do not attempt to replicate this without proper medical supervision. Any product sold outside official clinical trials claiming to be retatrutide is unverified and potentially dangerous.
Week One was Hell
In case you missed it, because of my uncooperative metabolism, my wife and I have resorted to getting retatrutide injections to aid us in our weight loss.
Week one started with a 2mg injection at the 1AM position above the navel, using a gauge 28 insulin syringe.
It hurt more than the Ozempic pen.
There were no immediate side effects that first night but hunger suppression was noticed almost immediately.
I was not reaching for food out of habit the way I normally would. I was eating because I needed to eat at a scheduled time.
We both experienced a little bit of nausea.
After reading the contraindications, I found out that this is consistent with how GLP-1 receptor agonists work: they slow gastric emptying (the rate at which food moves from your stomach to your intestines), which creates the sensation of fullness but can also create that uncomfortable in-between feeling. It was manageable. But it was there.
The part that surprised me most was the physical weakness.
Not fatigue exactly… more like a deflated quality to my energy.
I suspect this is less about the drug itself and more about eating significantly less without consciously adjusting the nutritional density of what I am eating.
When your calorie intake drops but you are still moving or doing light exercises, your body noticeably feels the deficit.
This is something I need to be more deliberate about going into week two.
Less food does not have to mean less nutrition if you are choosing what you eat carefully.
Week One by the Numbers
| Metric | Week One Observation |
| Dose administered | 2mg via insulin syringe, gauge 28 needle |
| Injection site | 1AM position, navel as centerpoint |
| Hunger suppression | Noticeable — appetite clearly reduced |
| Nausea | Present — mild to moderate, manageable |
| Physical energy | Reduced — likely nutritional deficit, not the drug itself |
| Weight loss | Not yet measurable — too early to assess |
Week Two Begins
Last night, my wife administered the second 2mg injection — this time at the 2 o’clock position, with the navel as centerpoint.
Rotating injection sites is standard practice to avoid tissue buildup or irritation at any single spot. The injection itself felt similar to last time.
We are staying at 2mg for now rather than escalating the dose, which aligns with the gradual titration (slow dose increase) approach used in clinical trials to minimize side effects.
There’s no weight loss to report yet.
Wish us luck!
Week three update coming. Watch this space.
DISCLAIMER
This article documents a personal weight loss journey and is for informational purposes only. It does not constitute medical advice and should not be used as a guide or template for personal medical decisions. The writer is not a doctor. Retatrutide is an investigational drug not approved by the FDA or the Philippine FDA. Products sold outside of official clinical trials claiming to be retatrutide are unverified and potentially dangerous. Please consult a licensed physician before beginning any weight loss medication program.
